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Clinical Care
Part I
ORAL AGENTS in T2DM MANAGMENT (OHAs)
If a patient is not optimally controlled by diet and exercise alone,
oral hypoglycemic agents (OHA's) are usually the first line of drug therapy
in the management of Type 2 diabetes.
Type 2 diabetes is characterized by three basic abnormalities that contribute
to the development of hyperglycemia:
A) Impaired insulin secretion by the pancreas;
B) Peripheral insulin resistance; and
C) Excessive glucose production by the liver;
Type 2 patients would have a combination of these three mechanisms which
cause the high blood glucose levels. The problem is that the extent and
severity of each of these mechanisms varies in different individuals,
and the oral agent which would be most optimal for any patient would depend
on which of these three mechanism plays a major role in their hyperglycemia.
Although there is no hard and fast rule for this, it is widely accepted
that in type 2 patients with low body weight, impaired insulin secretion
is the predominant defect, while insulin resistance tends to be less severe
than in the obese variety. Insulin resistance and hyperinsulinemia are
the classic abnormalities of obese individuals with type 2 diabetes.
All the oral agents available do not have the same mechanism of action.
Thus, one must know how a class of oral agent acts in order to choose
the appropriate drug.
Oral Agents commonly used in the Treatment of Type 2 Diabetes
| Agent |
Dose |
Duration of action |
Efficacy |
Major side effects |
Contraindications |
Sulfonylureas
Increase insulin secretion by pancreas;
Metabolizedprimarily liver, excreted by kidney |
|
|
Average decrease in FPG 60-80 mg%
Average decrease in HbA1c: 0.8- 2% |
Hypoglycemia; abdominal discomfort, nausea in around 1% to 3% patients;
hyperacidity, metallic taste or change in taste; weight gain; |
Significant renal or hepatic dysfunction |
| Glipizide |
2.5-20 mg/day |
8-12 hours |
|
Hypoglycemia risk
4-6% |
|
| Glibenclamide |
2.5-20 mg/day |
16-24 hours |
|
Hypoglycemia risk
4-6% |
|
| Gliclazide |
80-240mg/day |
6-8 hours |
|
Hypoglycemia risk
< 2% |
|
| Glimepiride |
1-8 mg/day |
24 hours |
|
Hypoglycemia risk
< 2% |
|
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Biguanides
Decreases hepatic glucose production
Not metabolized, eliminated by kidneys |
|
|
Average decrease in FPG 65-75 mg%
Average decrease in HbA1c: 1 - 2% |
Gastrointestinal discomfort, especially nausea; metallic taste in
mouth, loss of appetite; vitamin B12 deficiency, rarely lactic acidosis;
weight loss |
DKA, alcoholism, renal or hepatic dysfunction; congestive heart
failure; acute illness; cardiovascular collapse (shock); acute myocardial
infarction;septicemia; acute or chronic metabolic acidosis; respiratory
insufficiency; |
| Metformin |
500-1500 mg/ per day with meals |
8 hours |
|
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| |
Alpha-glucosidase inhibitors
Delays absorption of complex carbohydrates in intestinesNot absorbed
systemically |
To be taken with first bite of the meal |
|
Average decrease in FPG 25-30 mg%
Average decrease in HbA1c: 0.5 to1% |
Abdominal discomfort, bloating, "gas" formation, nausea
and diarrhea; |
liver disease, bowel or intestinal disease, intestinal obstruction |
| Acarbose |
25-100 mg with each meal |
4 Hours |
|
|
|
| Miglitol |
50-100mg. with each meal |
4 Hours |
|
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| Voglibose |
200mg with each meal |
|
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| |
Meglitinides
Increases pancreatic insulin secretion
Metabolized in the liver |
|
|
Average decrease in FPG 30-40 mg%
Average decrease in HbA1c: 0.5 to 0.7% |
Average decrease in FPG 30-40 mg%
Average decrease in HbA1c: 0.5 to 0.7%
Hypoglycemia; gastrointestinal upsets; muscle aches, URTI and flu-like
symptoms; body ache; |
Type 1 DM; diabetic ketoacidosis, hepatic dysfuntion |
| Repaglinide |
0.5-4 mg with each meal |
3 hours |
|
|
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| Nateglinide |
60-120 mg with each meal |
3 hours |
|
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Glitazones
Reduces insulin resistance at cellular level;
Metabolized in the liver |
Taken with or without food |
|
Average decrease in FPG 70-80 mg%
Average decrease in HbA1c: 1.5 - 2.5 % |
Weight gain, edema;URTI; toothaches; sore throat; body ache; headaches |
Hepatic dysfunction; CHF, increasing edema |
| Rosiglitazone |
4-8 mg/day |
12 hours |
|
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| Pioglitazone |
15-45 mg/day |
24 hours |
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| Recently, questions have been raised about cardiovascular
safety of rosiglitazone and it should be used with added caution.
It should not be used in patients with established cardiovascular
disease, elderly patients and along with insulin. Although, it is
not clear whether this is a class effect of glitazones, it would appear
prudent to be extra cautious even with the use of pioglitazone. If
pioglitazone is used along with insulin, the dose should not exceed
30mg/day. |
Recently, new agents known as incretin mimetics which act by increasing
endogenous incretin hormone effects have become available.
For a table on these new class of drugs, see Appendix 5a
| Protocols for
OHA THERAPY |
OHA THERAPY in a RELATIVELY non-obese Type 2 Diabetes patient
Protocol
Recently, questions have been raised about cardiovascular safety of rosiglitazone
and it should be used with added caution. Although, it is not clear whether
this is a class effect of glitazones, it would appear prudent to be extra
cautious even with the use of pioglitazone. Rosiglitazone should not be
used along wit insulin. The dose of pioglitazone should not be more than
30mg/day when used along with insulin.
In view of this, metformin may the drug of choice as a sensitizer
| Managing the
Overweight (Obese) Patient |
Protocol
Recently, questions have been raised about cardiovascular safety of rosiglitazone
and it should be used with added caution. Although, it is not clear whether
this is a class effect of glitazones, it would appear prudent to be extra
cautious even with the use of pioglitazone. Rosiglitazone should not be
used along wit insulin. The dose of pioglitazone should not be more than
30mg/day when used along with insulin.
In view of this, metformin may the drug of choice as a sensitizer.
Many trials have shown that a 20 mg dose of rimobanant, which is used
in the management of obese diabetics, can lead to an average weight loss
of approximately 6 kg over a year when accompanied with lifestyle therapies.
Importantly, it leads to a decrease in abdominal obesity and improves
cardiovascular risk factors. The most common reported side effects include
depression, anxiety, and nausea and should not be used in patients on
anti-depressives. It is NOT accepted for use by the U.S. FDA.
| GENERAL ASPECTS IN OHA THERAPY |
Theoretically, most Type 2 patients should be given a trial with diet
and exercise for an adequate period (usually 4-6 weeks) before using oral
hypoglycemic agents. But practically speaking, patients with fasting blood
glucose levels more than 200 mg%, or in patients with significant symptoms,
OHA therapy can be started along with diet and exercise. This will allow
a more rapid relief of symptoms.
The starting dose should be small as it is not possible to foretell how
a patient will respond to the oral agent.
OHA increments must be made in small amounts (half to one tablet at one
time) and gradually (every 1-2 weeks), till optimal control is reached.
In many patients, there will be a need to combine two or more oral agents
or even insulin therapy with possibly insulin sensitizers.
Combinations of submaximal doses of different classes of OHAs may be
equally effective as or more effective than maximum dose of monotherapy
in improving glucose control with fewer adverse effects.
Once Optimal Control Is Achieved
Re-enforce importance of diet and exercise;
Efforts must be made to reduce the dose slightly to see if the control
is maintained; the rationale for this is to try and obtain the optimal
target level for the individual with the smallest possible dose.
Emphasize need or regular follow-ups.
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