Causes and Classification of Erectile Dysfunction In most people with diabetes, problems with erection are due to nerve damage. All the same, it would be worthwhile to keep the other causes in mind especially the medications which can lead to erectile dysfunction. Sometimes, your doctor may just change the medication to another similar one which does not cause this problem. Which is also why you msut always tell your doctor the full list of medicines which you are taking, no matter how common these medicines may be and even if some other doctor has prescribed them for an associated condition.
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| Psychogenic Erectile Dysfunction |
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Neurogenic Erectile Dysfunction |
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Hormonal causes of Erectile Dysfunction |
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Vascular causes of Erectile Dysfunction |
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Erectile Dysfunction Due to Other Systemic Diseases and Aging |
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Drug-Induced Erectile Dysfunction
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| Causes of Erectile Dysfunction |
Psychologic causes
Young age with abrupt onset
Onset associated with specific emotional event
Dysfunction in certain settings while normal function in others
Persistence of nocturnal erections
Previous history of erectile dysfunction with spontaneous improvement
Excessive life stressors--work, relationships
Mental status findings suggestive of depression, psychosis or anxiety disorder
Penile injury/disease Peyronie's disease
Priapism
Anatomic abnormalities
Medications
| Aging
Chronic disease Diabetes mellitus
Heart disease
Hypertension
Lipid disorders
Renal failure
Liver disease
Vascular disease
Life style
Cigarette smoking
Chronic alcohol abuse
Organic causes
Vasculogenic--arterial
Persistent interest in sex
Older age with gradual onset
Impaired function in all settings
Presence of chronic disease (particularly diabetes, hypertension)
Use of prescription/over-the-counter medications associated with erectile dysfunction
Smoking
Elevated blood pressure, evidence of peripheral vascular disease (bruits, decreased pulses, skin and hair changes consistent with arterial insufficiency)
Vasculogenic--venous
Inability to maintain erection once established
Prior history of priapism
Local anomalies of thepenis | Neurogenic
History of spinal cord/pelvic trauma or surgery
Presence of chronic disease (diabetes, alcoholism)
Presence of neurologic condition (multiple sclerosis, stroke)
Abnormal neurologic examination of genitals/perineum
Hormonal
Loss of interest in sexual activity
Small atrophic testis
Low testosterone, elevated prolactin |
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Psychogenic Erectile Dysfunction
Most causes of erectile dysfunction were once considered to be psychogenic, but current evidence suggests that up to 80 percent of cases have an organic cause. Regardless of the primary etiology, a psychologic component frequently coexists. |
Psychogenic influences are the most likely causes of intermittent erectile failure in young men. |
Anxiety about "performance" may result in inhibitory sympathetic nervous system activity, and anticipatory anxiety can make the condition self perpetuating. Common causes of psychogenic erectile dysfunction include performance anxiety, a strained relationship, lack of sexual arousability, and overt psychiatric disorders such as depression and schizophrenia.
A psychogenic component is often present in older men, secondary to an organic cause.
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Neurogenic Erectile Dysfunction
Neurologic disorders such as Parkinson's disease, Alzheimer's disease, stroke, and cerebral trauma often cause erectile dysfunction by decreasing libido or preventing the initiation of an erection. In men with spinal cord injuries, the degree of erectile function depends largely on the nature, location, and extent of the lesion. Sensory involvement of the genitalia is essential to achieve and maintain reflexogenic erection, and this becomes more important as the effect of psychological stimuli abates with age.
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Hormonal Causes of Erectile Dysfunction
Androgen deficiency decreases nocturnal erections and libido. However, erection in response to visual sexual stimulation is preserved in men with hypogonadism, demonstrating that androgen is not essential for erection. Hyperprolactinemia from any cause results in both reproductive and sexual dysfunction because prolactin inhibits central dopaminergic activity and therefore the secretion of gonadotropin-releasing hormone, resulting in hypogonadotropic hypogonadism.
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Vascular Causes of Erectile Dysfunction
Common risk factors associated with generalized penile arterial insufficiency include hypertension, hyperlipidemia, cigarette smoking, diabetes mellitus, and pelvic irradiation. Focal stenosis of the common penile artery most often occurs in men who have sustained blunt pelvic or perineal trauma (e.g., from bicycling accidents). In men with hypertension, erectile function is impaired not by the increased blood pressure itself but by the associated arterial stenotic lesions.
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Failure of the veins to close during an erection (veno-occlusive dysfunction) can cause erectile dysfunction. Veno-occlusive dysfunction may be caused by the formation of large venous channels draining the corpora cavernosa, degenerative changes to the tunica albuginea (due to Peyronie's disease, old age, or diabetes mellitus) or traumatic injury (penile fracture), structural alterations of the cavernous smooth muscle and endothelium, poor relaxation of trabecular smooth muscle (in anxious men with excessive adrenergic tone), and shunts acquired as a result of operative correction of priapism.
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Erectile Dysfunction Due to Other Systemic Diseases and Aging
Sexual function progressively declines in healthy aging men. For example, the latent period between sexual stimulation and erection increases, erections are less turgid, ejaculation is less forceful, the ejaculatory volume decreases, and the refractory period between erections lengthens. There is also a decrease in penile sensitivity to tactile stimulation, a decrease in the serum testosterone concentrations, and an increase in cavernous muscle tone.
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Patients with diabetes mellitus have high rates of erectile dysfunction as a result of vascular disease and autonomic dysfunction. About 60-65 percent of men with chronic diabetes mellitus have erectile dysfunction. In addition to affecting small vessels, diabetes may affect the cavernous nerve terminals and endothelial cells, resulting in a deficiency of neurotransmitters.
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Chronic renal failure has frequently been associated with diminished erectile function, impaired libido, and infertility. The mechanism is probably multifactorial, involving low serum testosterone concentrations, vascular insufficiency, use of multiple medications, autonomic and somatic neuropathy, and psychological stress. Men with angina, myocardial infarction, or heart failure may have erectile dysfunction due to anxiety, depression, or concomitant penile arterial insufficiency.
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Drug-Induced Erectile Dysfunction
The drugs may have a direct effect or may act indirectly through bringing about nerve, vascular or hormonal imbalance.
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As many as 25 percent of cases of erectile dysfunction are related to medication side effects. If you are taking any of these drugs, please tell your doctor. At the same time, many patients only know their medications by their trade names, which is why it becomes so essential for you to tell the doctor all the medications you are on.
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The list given below is only that of allopathic, or what is called by many as "Western" medicines. Many people with diabetes, tend to take herbal medications in the hope of "curing" diabetes. Even medicines given by those practicing alternative medicines such as homeopathy, ayurveda, unani branches of medications may have erectile dysfunction as their side effects. It would be much better to discontinue these medications under medical guidance as they may be unknowingly the reason for your erection problems! .
As many as 25 percent of cases of erectile dysfunction are related to medication side effects.
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Drugs Causing Sexual Dysfunction |
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Drug/Drug Class |
Possible Alternative |
Antiarrhythmics
Amiodarone
Mexiletine
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Procainamide |
Anticonvulsants Carbamazepine
Ethosuximide
Phenytoin
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Valproic acid |
Antidepressants Amitriptyline
Amoxapine
Clomipramine
Doxepin
Maprotiline
Protriptyline
Trazodone
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Imipramine
Desipramine
* Some patients who experienced
sexual dysfunction with amoxapine
and clomipramine were successfully
switched to imipramine and desipramine,
respectively. |
Antihypertensives Atenolol Clonidine
Hydralazine
Labetolol
Methyldopa
Metoprolol
Pindolol
Prazosin
Propranolol
Verapamil
Reserpine
Guanethidine
Penbutolol,
Timolol
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Captopril
Enalapril
Diltiazem
Nifedipine |
Antipsychotic
Chlorpromazine
Haloperidol
Thioridazine
Trifluoperazine
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Loxapine |
Antispasmodic
Baclofen
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Dantrolene |
Diuretics
Amiloride
Indapamide
Thiazide diuretics
Spironolactone
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Furosemide |
Anti-Ulcer
Cimetidine
Ranitidine
Metoclopramide
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Famotidine |
Antihyperlipidemic
Clofibrate
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Gemfibrozil |
Non-Steroidal Anti-lnflammatory
Naproxen
Ibuprofen
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Diclofenac |
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