Diabetes India -Intracavernosal injections (ICI) Diabetes male erectile dysfunction you can do something about it

INTRACAVERNOSAL INJECTIONS (ICI)

Introduction
Prior to the advent of intracorporeal pharmacotherapy, or penile injections, penile prosthesis was the only thing other than drug therapy really available. The advent of penile injections began when a scientist working with dogs found that a drug injected into the penis produced an erection.

This drug was papaverine,. Papaverine was originally marketed for use in vascular surgery to dilate vessels and additionally was taken as an oral medication to act as a vasodilator in people with lower extremity ischemia and people with vascular diseases of the legs. The off-label indication was used extensively throughout the 1980s.

Ever since Virag, in 1982, discovered that the papaverine intracavernosal injection could induce a full erection, the self-injection has no longer been regarded as an alternative treatment, and became the first therapeutical option for organic impotence.

More papaverine was sold in the first year that this usage was discovered than had been sold in the prior thirty years!

Phentolamine is an alpha-adrenergic blocker used for hypertensive crises in pheochromocytoma. It came into reckoning for ICI when it was seen that papaverine gave better results when mixed with phentolamine.

Alprostadil was originally introduced to maintain the patency of the ductus arteriosus before definitive cardiac surgery could be undertaken. When it became apparent that it was effective in a penile self-injection program, it was then granted permission to be marketed as a treatment for erectile dysfunction.